When cosmic energy strikes the Earth, astronaut Stacy Macklin is given another chance to become Lady Lunar, but this time as a super-heroine! And she is not the only one, as she meets several other heroes and villains in similar situations: Karb-Brak the Andromedan, Remoni-Notra the second Star Sapphire, Moonman, Pulsar, and Skyman! To learn the secret of their cosmically restored powers, they must embark on an epic voyage to outer space! Meanwhile, various worlds are bombarded by mind-controlled armies bent on destruction! Who is behind this cosmic conquest? And what has all this got to do with a humble bookstore owner named Julius Leiber? Guest starring the Honor Team of Thronn, Queen Bee, Ron-Avon, and Genia, and introducing Cobol the Starknight!
As the remaining Earths begin to merge together, Brainiac and Lex Luthor of Earth-One have a plan to take them all! With an army of super-villains gathered from all five Earths, they mount a carefully planned invasion of Earth-Four, Earth-S, and Earth-X, swiftly defeating those worlds’ heroes. An army of super-heroes from Earth-One and Earth-Two soon arrive to free the other three Earths, but with the numbers favoring the villains, can the heroes rally to beat the odds? Guest starring the Justice League of America, the Justice Society of America, the New Teen Titans, the Outsiders, Infinity Inc., the Doom Patrol, the Marvel Family, the Freedom Fighters, and the Sentinels of Justice!